Viral Vector Core
The study of neural circuits requires an extensive and sophisticated interdisciplinary toolbox. Among these essential tools are customised recombinant viral particles, which allow scientists to introduce genes into genetically and/or anatomically defined groups of neurons so that they can precisely map neuronal connectivity, monitor neuronal activity, and manipulate this activity to test hypotheses about brain signalling and behaviour.
The Viral Vector Core (VVC) maintains high-titer stocks of commonly used adeno-associated and modified rabies viruses with specific pseudotypes, genetic promoters and cargo. The core also provides SWC researchers with a full molecular biology and viral particle production service for these classes of viral vector, aiming to become a hub for discussion, advice, assistance and support for any experimental troubleshooting or design involving the use of viral tools.