We have developed new open-source miniaturized microscopy tools to track neuronal population dynamics in a range of model species. These include wire-free miniaturized microscopes, microscopes integrated with large-scale electrophysiological recording capability and large field of view microscopes for rats and primates. We use these miniscopes in a model of temporal lobe epilepsy with cognitive deficits and demonstrate long-term instability of place cell firing and desynchronization of interneuron firing that may underlie the behavioral deficits. These tools are available for use by the neuroscience community at minimal cost to remove barriers for adaptation of the new technology.
Peyman Golshani received his BA in English and Neuroscience at UC Berkeley. He received his MD/PhD at UC Irvine under the direction of the late Dr. Edward G. Jones, on the development of function in the corticothalamic circuit. He completed a neurology residency at UCLA and has a been a professor in the departments of neurology and psychiatry, where his lab focuses on discovering changes in neural dynamics that drive cognitive deficits in models of neurological and neurodevelopmental disorders. He also leads an effort to develop open-source miniaturized microscopes.
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