Neural circuit analysis relies on having molecular markers for specific cell types. However, for a cell type identified only by its circuit function, the process of identifying markers remains laborious. I will describe physiological optical tagging sequencing (PhOTseq), a new technique for tagging and expression profiling of cells on the basis of their functional properties. I will also share findings from using this technique to learn more about the relationship between receptor genes and response properties in the sensory neurons of the mouse vomeronasal system.
Timothy Holy is the Alan A. and Edith L. Wolff Professor of Neuroscience at Washington University in St. Louis. My research weaves together technology development, physiology, cellular and molecular tools, and computation to tackle questions in the neural control of behavior. My other contributions include co-directing the Neuroscience Ph.D. Program and the development of the Julia programming language.
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